|
Estimated prevalence of some common markers in Trisomy 21 and euploid fetuses and the likelihood ratio (LR) for Trisomy 21 at the second trimester scan according to existing literature |
|||||
|
Marker |
Detection rate |
False Positive rate |
Positive LR |
Negative LR |
LR isolated marker |
|
Intracardiac echogenic focus |
24.4 |
3.9 |
5.85 |
0.8 |
0.95 |
|
Ventriculomegaly |
7.5 |
0.3 |
25.78 |
0.94 |
3.57 |
|
Increased nuchal fold |
26.2 |
1.2 |
19.18 |
0.8 |
3.12 |
|
Echogenic bowel |
16.7 |
1.1 |
11.44 |
0.9 |
1.65 |
|
Mild hydronephrosis |
13.7 |
1.4 |
7.77 |
0.92 |
1.10 |
|
Short humerus |
30.3 |
4.6 |
4.81 |
0.74 |
0.78 |
|
Short femur |
27.7 |
6.4 |
3.72 |
0.8 |
0.61 |
|
Aberrant right subclavian artery |
30.7 |
1.5 |
21.48 |
0.71 |
3.94 |
|
Absent or hypoplastic nasal bone |
59.8 |
2.8 |
23.26 |
0.46 |
6.58 |
